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IsoEnergy Summer Drilling Intersects Multiple Areas of Radioactivity Highlighting the Prospectivity of the Larocque Trend

Exploration Programs

IsoEnergy Summer Drilling Intersects Multiple Areas of Radioactivity

Highlighting the Prospectivity of the Larocque Trend

– Aggressive Follow-up Winter Drill Program Planned –

Toronto, ON, November 6, 2024 – IsoEnergy Ltd. (“IsoEnergy” or the “Company”) (TSX: ISO; OTCQX:

ISENF) is pleased to announce completion of its expanded summer exploration program at the Larocque

East Project (the “Project”), located in the eastern Athabasca Basin (Figure 1). The Company successfully

completed 30 diamond drill holes, totaling 13,015m, exceeding the originally budgeted 9,825m, along the

Larocque Trend (“Larocque Trend”), an important regional structure that hosts the world-class Hurricane

Deposit (“Hurricane”) and other notable high -grade occurrences including those on Cameco/Orano’s

Dawn Lake joint venture (Figure 2). Drilling test ed multiple target s identified through Ambient Noise

Tomography (“ANT”) surveys across 9km of the Laroque Trend on the Project.

Highlights

• Drilling confirmed prospectivity for additional mineralization at the Project regionally through

the identification of two new high priority zones (Areas D and E) and immediately adjacent to

Hurricane, referred to as Hurricane East (Figure 3).

• First pass drilling in Areas D and E returned elevated radioactivity associated with significant

alteration, enhancing the prospectivity of the Project's eastern extent.

o In Area E, a 1km by 2km ANT anomaly located 8km east of Hurricane, five holes were

drilled highlighted by h ole LE24-192 which intersected 2.0m at 4 95 parts per million

uranium partial (“ppm U-p”) and 3,410 counts per second (“cps”), including 0.5m at 1,110

ppm U-p and 7,483 cps (Figure 4).

o In Area D, a 2.5km by 1km ANT anomaly located 8 km east of Hurricane, five holes were

drilled highlighted by hole LE24-174 which intersected 3.5m, from 254m, at 26.2 ppm U-

p and 257 cps and 0.2m at 1,303 cps (Figure 5).

o These results are comparable to pre-discovery holes drilled by Cameco just 40 meters

from the high-grade Hurricane Deposit, KER-11, which returned 0.5m at 518.0 ppm U -p

and KER-12 (Figure 4). We believe this emphasizes the strong proximal potential within

the geochemical halos of the known deposits, where sharply defined uranium

mineralization boundaries are evident.

• Drilling in Hurricane East with in 600 meters of Hurricane returned elevated radioactivity,

indicating potential for resource expansion.

o A single hole drilled 290m east of Hurricane , LE24-188, intersected 2.1m at 1,847 cps,

indicating a potential for near resource expansion (Figure 6).

o In Area B, a 250m by 180m ANT target anomaly centred 500m east of Hurricane, seven

holes were drilled. Hole LE24-165 intersected 6.0 m at 1,359 cps, including a higher-grade

interval of 0.5m at 3,067 cps.

o These results suggest that the Hurricane resource may remain open for further expansion.

• Additional results are expected in the coming weeks with 33% of the geochemical results

received to date (Table 1). Initial results are highly encouraging, with strong hydrothermal

alteration and elevated geochemical signatures – key indicators typically associated with uranium

mineralization.

• Follow up drilling commencing in January 2025 is currently anticipated with a focus on high-

priority areas including D, E and Hurricane East, as well as additional first pass drilling in other

untested ANT anomalies (Figure 3).

Dr. Dan Brisbin, Vice President Exploration, commented, “Our summer drill results at Larocque East

are highly encouraging. The structural disruption, bleaching, desilicification and clay alteration

intersected within and adjacent to the ANT velocity anomalies are all hallmarks of Athabasca uranium

deposits. T he significantly anomalous radioactivity and sandstone uranium geochemistry are

indicative of the fertility of these altera tion zones ; and several kilometr es of strike length along

graphitic-pyritic conductor corridors east of the Hurricane Deposit provide ample exploration space

for potential additional discoveries along the Hurricane trend.”

Figure 1 – Location map of the Hurricane Deposit and IsoEnergy’s exploration projects, including the

Larocque East project, in the eastern Athabasca Basin.

The Larocque Trend is a northeast-trending regional structural feature that extends over 160 kilometres,

hosting numerous anomalous uranium occurrences (Figure 2). Most notably, it is home to the Hurricane

Deposit, a discovery that has significantly enhanced the prospectivity of the entire trend, further

underscoring its potential for additional high-grade uranium discoveries.

Figure 2 – Location map of the Larocque Trend spanning across IsoEnergy’s projects.

Recent exploration drilling and geophysical programs have successfully defined the alteration and

geochemical footprint of the Hurricane Deposit. While the mineralized footprint is relatively small—

ranging from 20 to 125 meters wide, 375 meters long, and 2 to 12 meters thick (Figures 4 )—it is hosted

within a much larger zone of hydrothermal clay alteration, spanning up to 500 meters wide, 1 km long,

and 200 to 300 meters thick. Within this broader alteration zone, the boundaries of the uranium

mineralization are remarkably sharp and have been precisely delineated by drilling (Figure 4 ). Typically,

uranium grades in the Hurricane Deposit decline sharply, dropping from greater than 1% to less than 20

ppm U-p over 30 metres in the both the horizontal and vertical directions. This abrupt decrease in uranium

grade over such short distances presents a challenge in identifying additional high-grade zones. However,

the broader, low-level geochemical signature of uranium mineralization provides a larger, more accessible

target for initial drill testing, offering valuable vectors for potential follow-up drilling. This understanding

has informed the design and analysis of the recent summer drill program (Figure 3), with drilling in seven

of ten ANT anomalous target areas defined by 2023 and 2024 surveys . As a result, three target areas –

East Hurricane, D and E – have been prioritized for future drill testing, with the details of the high priority

targets reviewed in figures and tables below. Integration of new geological, mineralogical, geochemical

and geophysical (ANT) information obtained in 2024 with historical information is already underway to

generate new drill targets.

Figure 3 – ANT survey targets across the eastern portion of the Larocque East Project with 2024

summer drill holes and respective section locations for Areas D, E and Hurricane East.

Figure 4 – Cross-sections of the Hurricane Deposit, including pre-discovery holes KER-11 and KER-12

(left), illustrating the geochemical halo surrounding to the deposit, as a guide for interpreting

exploration drill results along the trend and Area E section showing comparable results in drill hole

LE24-192 (right) which intersected elevated radioactivity and hydrothermal alteration proximal to

unconformity (175 m below surface).

Figure 5 – Area D Section showing drill holes LE24-174 and LE24-183 which intersected moderately

bleached sandstone. Elevated radioactivity coincident with pervasive clay alteration in basement in

drill hole LE24-174 is indicative of potential basement mineralization at Larocque East.

Figure 6 – Hurricane East Section showing drill hole LE24-188 which intersected strong bleaching and

clay typical of Hurricane Deposit alteration. Approximately 290 meters east of Hurricane Deposit.