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IsoEnergy Provides Update on Winter Results and Announces Summer Exploration Plans

Exploration Programs

IsoEnergy Provides Update on Winter Results and Announces Summer Exploration Plans

Saskatoon, SK, July 15, 2022 – IsoEnergy Ltd. (“IsoEnergy” or the “Company”) (TSXV: ISO; OTCQX: ISENF)

is pleased to provide an update on its winter exploration results and to announce its summer 2022

exploration plans for its eastern Athabasca Basin uranium properties (Figure 1).

Winter Assay Results and Geophysical Surveys Update

Larocque East Project

Chemical assays are summarized in Table 1 for the final two drill holes which intersected radioactivity

>500 CPS during the winter of 2022. At the Hurricane zone, LE22-115A targeted the unconformity 75m

west of LE21-101 and intersected 2.0m averaging 1.0% U3O8 between 335.0m and 337.0m which includes

a 0.5m subinterval averaging 3.3% U 3O8 from 335.5 to 336.0m. Approximately 3.8km to the east -

northeast, LE22 -116 intersected 0.5m averaging 0.4% U 3O8 from 282.0m to 282.5m. Neither result is

considered to warrant direct follow -up at this time. Figures 3 and 4 show the locations of LE22 -116 and

LE22-115A, respectively.

Table 1 – Larocque East Winter 2022 Assay Results

Notes:

1. Radioactivity is total gamma from drill core measured with an RS-125 hand-held spectrometer

2. Radioactivity previously disclosed

Hawk Project

Electromagnetic surveying completed at Hawk during the winter of 2022 advanced the project to a drill-

ready state. With multiple conductive responses mapped on each of six survey lines , the winter work

generated a drill target inventory that exceeded IsoEnergy’s expectations. The Hawk project contains over

10km of prospective magnetic low zones hosting conductors with depths to the unconformity expected

to be between 600m and 750m. The single historical drill hole completed within the project failed to

intersect conductive basement, indicating that none of the prospective stratigraphy has been effectively

tested. A first pass drilling campaign to follow up the 2022 results is planned for 2023. Figure 5 shows the

Hawk survey area and interpreted results.

U3O8 (%) Ni (%)

LE22-115A2 335.0 337.0 2.0 >500 1.0 0.1 180/-80 434.0

incl. 335.5 336.0 0.5 >5,000 3.3 0.0

LE22-1162 282.0 282.5 0.5 >500 0.4 0.0 345/-60 432.5

Hole-ID From

(m)

To

(m)

Length

(m)

Chemical Assays Orientation

(Azm/Dip)

Hole Length

(m)

Radioactivity1

(CPS)

Ranger Project

As at Hawk, electromagnetic surveying completed at Ranger during winter 2022 advanced the project to

a drill-ready state. The winter survey work mapped weakly to moderately conductive trends in two areas.

The northwestern conductive trends are associated with magnetic breaks and are completely untested by

drilling within the project. The southern conductive trends are associated with a magnetic break and the

projection of the Bird Lake Fault, a significant post -Athabasca structure which has a vertical offse t of up

to 80m. The depth to the unconformity in the survey area is expected to between 230 and 300m. A first

pass drilling campaign to follow up the 2022 results in planned for 2023. Figure 6 shows the Ranger winter

2022 survey results.

Summer Exploration Plans

Highlights:

• Diamond drilling at Larocque East, Geiger, and Trident totalling 7000m

• Airborne geophysical surveying at Evergreen, Spruce, East Rim, Edge, and Full Moon

Tim Gabruch, President and Chief Executive Officer commented: “As we move towards an initial Mineral

Resource Estimate for Hurricane and plan the next stage of advancement on that project, we will continue

to advance exploration on the eastern side of our Larocque East property and in parallel focus on

additional properties in our high-quality exploration portfolio.”

Andy Carmichael, Vice President of Exploration commented: “The second half of 2022 will see IsoEnergy

explore eight projects spread throughout the eastern Athabasca region. We are excited to resume drilling

at Larocque East and Geiger, and initial reconnaissance drilling at Trident will provide valuable geological

information on this underexplored project which is immediately adjacent to the Athabasca Basin.

Additionally, an extensive program of airborne surveying will move several of our early -stage projects

toward drill-readiness.”

Diamond Drilling:

Larocque East Project

Drilling at Larocque East will comprise six drill holes totalling 2000 m. The main objectives of the drilling

are to continue exploring the Larocque Lake conductive trend and to assess the prospectivity of the

Kernaghan trend. Drilling on the Larocque Lake trend will follow -up strongly anomalous geochemistry

within two kilometres along strike of the Hurricane zone and test high-priority geophysical targets in the

eastern portion of the project. On the Kernaghan trend, where historical drilling identified over 40 m of

unconformity topography associated with anomalous geochemistry in the Athabasca sandstones, drilling

will test for significant basement structures which would warrant follow-up. Figure 3 shows the general

target areas for Larocque East drilling.

Geiger Project

Eight holes totalling 3000m are planned at Geiger. Drilling will follow-up winter 2022 geophysical results

in the Q23 and Q48 areas where electromagnetic (EM) surveying mapped more than 35km of conductor

strike. The objective of the summer 2022 Geiger drilling is to assess these areas for the presence of

significant structures which would warrant additional follow -up. The depth to the unconformity in the

two target areas is approximately 250 to 275m. Figure 7 shows the planned drilling areas and winter 2022

geophysical survey results.

Trident Project

Drilling planned at Trident comprises eight drill holes totalling 2000 m. Four target areas at Trident

identified by IsoEnergy are characterized by the presence of electromagnetic (EM) conductors hosted

within zones of low magnetic susceptibility which are not covered by large waterbodies. As at Larocque

East and Geiger, the primary objective of drilling is to assess the target areas for the presence of

favourable basement structures which would warrant further exploration. Figure 8 shows the Trident

2022 drilling target areas.

Airborne Geophysical Surveying:

Xcalibur Multiphysics has been engaged to conduct multiparameter airborne geophysical surveying at

IsoEnergy’s early-stage Evergreen, Spruce, East Rim, Edge and Full Moon projects. The survey will employ

Xcalibur’s FALCON® Airborne Gravity Gradiometry system to acquire high -resolution gravity, magnetic,

and radiometric (spectrometry ) datasets . Gravity and magnetic data will improve the property-wide

understanding of basement geology and assist in the identification of potential alteration zones, while

radiometry aims to locate anomalous radioactivity related to near -surface showings and radioactive

boulder trains such as those that led to the discovery of several notable uranium deposits including Triple

R and Key Lake. Survey work commenced o n June 29th and is expected to be completed in mid -July.

Project locations are shown on Figure 1.

The Larocque East Property and the Hurricane Zone

The 100% owned Larocque East property consists of 33 mineral claims totaling 16,780ha. Two of the

project’s claims distal to the Hurricane zone are subject to a 2% Net Smelter Returns Royalty of which 1%

may be bought back for $1 million at IsoEnergy’s discretion. Larocque East is immediately adjacent to the

north end of IsoEnergy’s Geiger property and is 35km northwest of Orano Canada’s McClean Lake uranium

mine and mill.

Along with other target areas, the Larocque East Property covers a 15-kilometre-long northeast extension

of the Larocque Lake conductor system; a trend of graphitic metasedimentary basement rocks that is

associated with significant uranium mineralization at the Hurricane zone, and in several occurrences on

Cameco Corp. and Orano Canada Inc.’s neighbouring property to the southwest of Larocque East . The

Hurricane zone was discovered in July 2018 and was followed up with 29 drill holes in 2019, 48 drill holes

in 2020, 16 drill holes in 2021 , and five drill holes during winter 2022 . Dimensions are currently 375m

along-strike, up to 125m wide, and up to 12m thick . The zone is open for expansion along- strike to the

north and south on some sections . Mineralization is polymetallic and commonly straddles the sub -

Athabasca unconformity 325m below surface. The best intersection to date is 38.8% U 3O8 over 7.5m in

drill hole LE20 -76. Drilling at Cameco Corp.’s Laroc que Lake zone on the neighbouring property to the

southwest has returned historical intersections of up to 29.9% U3O8 over 7.0m in drill hole Q22-040. Like

the nearby Geiger property, Larocque East is located adjacent to the Wollaston-Mudjatik transition zone

- a major crustal suture related to most of the uranium deposits in the eastern Athabasca Basin .

Importantly, the sandstone cover on the Property is thin, ranging between 140m and 450m in previous

drilling.

Figure 1 – IsoEnergy Athabasca Projects

Figure 2 – Larocque East Location Map

Figure 3 – Larocque East Drilling Areas

Figure 4 – Hurricane Winter 2022 Drilling Results

Figure 5 – Hawk Survey Results

Figure 6 – Ranger Survey Results

Figure 7 – Geiger Drilling Areas

Figure 8 – Trident Drilling Areas

Qualified Person Statement

The scientific and technical information contained in this news release was prepared by Andy Carmichael,

P.Geo., IsoEnergy’s Vice President, Exploration, who is a “Qualified Person” (as defined in NI 43 -101

– Standards of Disclosure for Mineral Projects ). Mr. Carmichael has verified the data disclosed. All

radioactivity measurements reported herein are total gamma from an RS -125 hand-held spectrometer.

As mineralized drill holes at the Hurricane zone are oriented very steeply (-70 to -90 degrees) into a zone

of mineralization that is interpreted to be ho rizontal, the true thickness of the intersections is expected

to be greater than or equal to 90% of the core lengths. This news release refers to properties other than

those in which the Company has an interest. Mineralization on those other properties is not necessarily

indicative of mineralization on the Company’s properties. All chemical analyses are completed for the

Company by SRC Geoanalytical Laboratories in Saskatoon, SK. For additional information regarding the

Company’s Larocque East Project, inc luding its quality assurance and quality control procedures, please

see the Technical Report dated effective May 15, 2019, on the Company’s profile at www.sedar.com.

About IsoEnergy

IsoEnergy is a well-funded uranium exploration and development company with a portfolio of prospective

projects in the eastern Athabasca Basin in Saskatchewan, Canada. The Company recently discovered the

high-grade Hurricane Zone of uranium mineralization on its 100% owned Larocque East property in the

Eastern Athabasca Basin. IsoEnergy is led by a Board and Management team with a track record of success

in uranium exploration, devel opment, and operations. The Company was founded and is supported by

the team at its major shareholder, NexGen Energy Ltd.