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IsoEnergy Intersects Strong Radioactivity in Three New Southern Extension Drill Holes Zone of Intense Mineralization Continues to Expand in the Southern Extension Area

Exploration Programs

IsoEnergy Intersects Strong Radioactivity in Three New Southern

Extension Drill Holes

Zone of Intense Mineralization Continues to Expand in the Southern Extension Area

Vancouver, BC, Octo ber 15, 2020 – IsoEnergy Ltd. (“IsoEnergy” or the “ Company”) (TSXV: ISO; OTCQX: ISENF) is

pleased to report additional intersections of strong radioactivity from the on-going drilling program at the Hurricane

zone. The Hurricane zone is a recent discovery of high-grade uranium mineralization on the Company’s 100% owned

Larocque East property (the “Property”) in the Eastern Athabasca Basin of Saskatchewan (Figure 1).

Highlights:

• South Extension drill hole LE20-68 intersected 11.0m of uranium mineralization (>500 CPS), including 1.5m

of very strong mineralization (>50,000 CPS),

• South Extension drill hole LE20- 69 intersected 6.5m of uranium mineralization (>500 CPS), including 1.0m

of strong mineralization (>5,000 CPS),

• South Extension drill hole LE20-72 intersected 6.0m of uranium mineralization (>500 CPS), including 1.5m

of very strong mineralization (>40,000 CPS)

• Hurricane zone footprint has now been extended 38 m to the south on section 4435E , more than doubling

the width of the high-grade mineralization

Note: Radioactivity is total gamma counts per second (CPS) from drill core measured with an RS-125 hand-held spectrometer

(RS-125).

Craig Parry, Chief Executive Officer commented: “Following up on the very high- grade assays released earlier this

week, I’m pleased to report that IsoEnergy continues to deliver outstanding uranium intersections at the Hurricane

zone, just 320m below surface.”

Steve Blower, Vice President of Exploration commented: “The southern extension drill holes completed to date have

expanded the footprint of the intensely mineralized portion of the Hurricane zone. We will continue to evaluate this

area with the five remaining drill holes in the program.”

LE20-68 (Section 4485E)

Completed to evaluate the potential to expand mineralization south on section 4485E (Figures 2 and 3), drill hole

LE20-68 successfully intersected 11.0m of uranium mineralization (>500 CPS) from 323.0 to 334.0m, including a

subinterval of very strong radioactivity (>50,000 CPS) from 332.0 to 333.5m. This result increases the width of the

zone on this section by at least 10m. As with all drill holes to date at the Hurricane zone, the mineralization is located

at the sub-Athabasca unconformity.

LE20-69 (Section 4435E)

Designed to follow-up on the intense uranium mineralization intersected previously in drill hole LE20 -64 on section

4435E, LE20- 69 was completed 8m southeast of LE20 -64 (Figures 2 and 4). It intersected 6.5m of uranium

mineralization (>500 CPS) from 322.5m to 329.0m, including 1.0m of strong mineralization (>5,000 CPS) from 325.0

to 326.0m. This result expands the Hurricane zone footprint at least 8m south of drill hole LE20- 64 on this section,

and summer drilling has now expanded the zone a total of 38m to the south.

LE20-72 (Section 4460E)

Drill hole LE20-72 (Figures 2 and 5) was designed to evaluate the potential to extend mineralization south on section

4460E. It intersected 6.0m of uranium mineralization (>500 CPS) from 320.5 to 326.5m, including 1.5m of very strong

mineralization (>40,000 CPS) from 324.5 to 326.0m. This result expands the Hurricane zone footprint at least 10m

south on this section.

Other Drill Holes

Drill holes LE20-70 and LE20-71 were completed on the south end of sections 4560E and 4485E, respectively (Figures

2 and 3). Drill hole LE20-71 intersected 2.0m of uranium mineralization (>500 CPS) from 327.5 to 329.5m, including

0.5m of strong uranium mi neralization (>20,000 CPS), 16m south of drill hole LE20- 68. Drill hole LE20 -70, located

18m south of LE19-03 on the discovery section 4560E was not significantly mineralized.

Next Steps

Five drill holes remain in this expanded drill program . All will be completed on the western end of the Hurricane

zone. Samples are periodically shipped to the analytical laboratory in Saskatoon. Chemical assay results generally

follow within three to four weeks of the shipping dates.

The Larocque East Property and the Hurricane Zone

The 100% owned Larocque East p roperty consists of 31 mineral claims totaling 15,878ha that are not encumbered

by any royalties or other interests. Larocque East is immediately adjacent to the north end of IsoEnergy’s Geiger

property and is 35km northwest of Orano Canada’s McClean Lake uranium mine and mill.

Along with other target areas, the Property covers a 15 -kilometre-long northeast extension of the Larocq ue Lake

conductor system; a trend of graphitic metasedimentary basement rocks that is associated with significant uranium

mineralization at the Hurricane zone, and in several occurrences on Cameco Corp . and Orano Canada Inc.’s

neighbouring property to the southwest of Larocque East. The Hurricane zone was discovered in July 2018 and was

followed up with 29 drill holes in 2019 and an additional 14 drill holes to date in 2020. Dimensions are currently

575m along-strike, 40m wide, and up to 11m thick. The z one is open for expansion along -strike to the east and on

most sections. Mineralization is polymetallic and commonly straddles the sub-Athabasca unconformity 320 m below

surface. The best intersection to date is 33.9% U 3O8 over 8.5m in drill hole LE20- 34. Drilling at Cameco Corp.’s

Larocque Lake zone on the neighbouring property to the southwest has returned historical intersections of up to

29.9% U3O8 over 7.0m in drill hole Q22- 040. Like the nearby Geiger property, Larocque East is located adjacent to

the Wollaston -Mudjatik transition zone - a major crustal suture related to most of the uranium deposits in the

eastern Athabasca Basin. Importantly, the sandstone cover on the Property is thin, ranging between 140m and 330m

in previous drilling.

Table 1 – Summer 2020 Drilling Program Results

Hole-ID From (m) To (m) Length (m) Radioactivity1,2 Chemical Assays Orientation Location

(CPS) U3O8 (%) Ni (%) (Azm/Dip)

LE20-544 329.5 338.5 9.0 >500 12.8 3.9

180/-79 Sect 4510E incl. 333.0 337.0 4.0 >30,000 27.1 5.2

incl. 334.0 334.5 0.5 Off-scale5 52.5 1.6

LE20-554 No significant mineralization 180/-70 Sect 4785E

LE20-564 351.0 358.5 7.5 >500 0.1 0.1 180/-70 Sect 4660E

LE20-574 343.8 353.8 10.0 >500 11.7 0.3

217/-70 Sect 4435E incl. 347.3 349.8 2.5 >40,000 46.0 1.0

incl. 347.8 348.3 0.5 Off-scale5 65.9 0.7

LE20-58 Abandoned before target 180/-69 Sect 4785E

LE20-58C14,6 144.0 146.5 2.5 >500 0.2 0.1 180/-71 Sect 4785E

LE20-594 342.0 347.0 5.0 >500 0.2 0.2 112/-69 Sect 4610E incl. 345.0 345.5 0.5 >5,000 0.9 0.2

LE20-60 No significant mineralization 000/-90 Sect 4660E

LE20-614 313.0 322.0 9.0 >500 0.3 0.0 000/-90 Sect 4660E incl. 321.5 322.0 0.5 >10,000 1.4 0.2

LE20-624 314.0 316.5 2.5 >500 0.2 0.0

000/-90 Sect 4435E and 321.0 325.5 4.5 >500 6.2 0.5

incl. 323.0 325.5 2.5 >30,000 11.1 0.3

incl. 324.5 325.0 0.5 Off-scale5 29.0 0.3

LE20-63A No significant mineralization 180/-85 Sect 4660E

LE20-644 316.5 320.0 3.5 >500 0.3 0.1

000/-90 Sect 4435E and 324.0 329.0 5.0 >500 48.8 1.1

incl. 324.5 328.5 4.0 >30,000 57.5 1.3

LE20-65 No significant mineralization 000/-90 Sect 4610E

LE20-664 323.0 324.0 1.0 >500 Pending 000/-90 Sect 4785E

LE20-674 327.5 329.5 2.0 >500 Pending 000/-90 Sect 4435E

LE20-68 323.0 334.0 11.0 >500 Pending 180/-80 Sect 4485E

incl. 332.0 333.5 1.5 >50,000

LE20-69 322.5 329.0 6.5 >500 Pending 000/-90 Sect 4435E

incl. 325.0 326.0 1.0 >5,000

LE20-70 No significant mineralization 000/-90 Sect 4560E

LE20-71 324.0 325.0 1.0 >500 Pending 000/-90 Sect 4485E

and 327.5 329.5 2.0 >500

incl. 329.0 329.5 0.5 >20,000

LE20-72 320.5 326.5 6.0 >500 Pending 000/-90 Sect 4460E

incl. 323.0 323.5 0.5 >20,000

and incl. 324.5 326.0 1.5 >40,000

Notes: 1. Radioactivity is total gamma from drill core measured with an RS-125 hand-held spectrometer

2. Measurements of total gamma on drill core are an indication of uranium content, but may not correlate with chemical assays

3. Radioactivity previously disclosed

4. Radioactivity and chemical assays previously disclosed

5. Off-scale radioactivity is defined as exceeding 65,536 cps, the maximum measurable by an RS-125 spectrometer

6. LE20-58C1 is a wedged off-cut from LE20-58 at 200m

Figure 1 – Larocque East Property Map

Figure 2 – Hurricane Zone Drill Hole Location Map

Figure 3 – Vertical Cross-Section 4485E (Drill Holes LE20-68 and 71)

Figure 4 – Vertical Cross-Section 4435E (Drill Hole LE20-69)

Figure 5 – Vertical Cross-Section 4460E (Drill Hole LE20-72)