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ISO.TO ·

IsoEnergy Grants Stock Options

Share Capital & Compensation

IsoEnergy Grants Stock Options

Saskatoon, SK, March 1, 2023 – IsoEnergy Ltd. (“IsoEnergy”) (TSXV: ISO; OTCQX: ISENF) announces today

that in connection with the appointment of Darryl Clark as the Company’s Vice President, Exploration,

effective today, Dr. Clark has been granted 300,000 incentive stock options (the “Options”). The Options

are exercisable at a price of $3.06, vest in three equal annual instalments commencing on the grant date

and have a term of five years. The Options were granted pursuant to the Company’s incentive stock option

plan and are subject to regulatory approval.

About IsoEnergy

IsoEnergy is a well-funded uranium exploration and development company with a portfolio of prospective

projects in the infrastructure -rich eastern Athabasca Basin in Saskatchewan, Canada. In 2018, the

Company discovered the high-grade Hurricane Deposit on its 100% owned Larocque East property in the

Eastern Athabasca Basin. The Hurricane Deposit has Indicated Mineral Resources of 48.61 Million lb U3O8

based on 63,800 tonnes grading 34.5% U3O8 and Inferred Mineral Resources of 2.66 Million lb U3O8 based

on 54,300 tonnes grading 2.2% U3O8 (July 8, 2022). The Hurricane Deposit is 100% owned by IsoEnergy

and is unencumbered from any royalties. IsoEnergy is led by a Board and Management team with a track

record of success in uranium exploration, development, and operations. The Company was founded and

is supported by the team at its major shareholder, NexGen Energy Ltd.

Tim Gabruch

Chief Executive Officer

IsoEnergy Ltd.

+1 306 261-6284

[email protected]

www.isoenergy.ca

Investor Relations

Kin Communications

+1 604 684 6730

[email protected]

www.isoenergy.ca

Neither the TSX Venture Exchange nor its Regulations Services Provider (as that term is defined in the policies of

the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

This news release shall not constitute an offer to sell or a solicitation of any offer to buy any securities, nor shall

there be any sale of any securities in any jurisdiction in which such offer, solicitation or sale would be unlawful. The

securities referenced herein have not been, nor will they be, registered under the United States Securities Act o f

1933, as amended (the “U.S. Securities Act”), and such securities may not be offered or sold within the United States

absent registration under the U.S. Securities Act or an applicable exemption from the registration requirements

thereunder.

Forward-Looking Information

The information contained herein contains “forward- looking statements” within the meaning of the United States

Private Securities Litigation Reform Act of 1995 and “forward-looking information” within the meaning of applicable

Canadian securities legislation. “Forward -looking information” includes, but is not limited to, statements with

respect to the activities, events or developments that the Company expects or anticipates will or may occur in the

future, including, without limitation, planned exploration activities. Generally, but not always, forward- looking

information and statements can be identified by the use of words such as “plans”, “expects”, “is expected”,

“budget”, “scheduled”, “estimates”, “forecasts”, “intends”, “anticipates”, or “believes” or the negative connotation

thereof or variations of such words and phrases or state that certain actions, events or results “may”, “could”,

“would”, “might” or “will be taken”, “occur” or “be achieved” or the negative connotation thereof.

Such forward-looking information and statements are based on numerous assumptions, including among others,

that the results of planned exploration activities are as anticipated, the price of uranium, the anticipated cost of

planned exploration activities, that general business and economic conditions will not change in a material adverse

manner, that financing will be available if and when needed and on reasonable terms, that third party contractors,

equipment and supplies and governmental and other approval s required to conduct the Company’s planned

exploration activities will be available on reasonable terms and in a timely manner. Although the assumptions made

by the Company in providing forward- looking information or making forward- looking statements are considered

reasonable by management at the time, there can be no assurance that such assumptions will prove to be accurate.

Forward-looking information and statements also involve known and unknown risks and uncertainties and other

factors, which may cause actual events or results in future periods to differ materially from any projections of future

events or results expressed or implied by such forward-looking information or statements, including, among others:

negative operating cash flow and dependence o n third party financing, uncertainty of additional financing, no

known mineral reserves or resources, the limited operating history of the Company, the influence of a large

shareholder, alternative sources of energy and uranium prices, aboriginal title and consultation issues, reliance on

key management and other personnel, actual results of exploration activities being different than anticipated,

changes in exploration programs based upon results, availability of third party contractors, availability of equipment

and supplies, failure of equipment to operate as anticipated; accidents, effects of weather and other natural

phenomena and other risks associated with the mineral exploration industry, environmental risks, changes in laws

and regulations, community relations and delays in obtaining governmental or other approvals.

Although the Company has attempted to identify important factors that could cause actual results to differ

materially from those contained in the forward- looking information or implied by forward -looking information,

there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no

assurance that forward-looking information and statements will prove to be accurate, as actual results and future

events could differ materially from those anticipated, estimated or intended. Accordingly, readers should not place

undue reliance on forward -looking statements or information. The Company undertakes no obligation to update

or reissue forward -looking information as a result of new information or events except as required by applicable

securities laws