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IsoEnergy Completes Summer 2021 Drilling at Hurricane, Reports Strong Mineralization in Drill Hole LE21-107

Drill Results Exploration Programs

IsoEnergy Completes Summer 2021 Drilling at Hurricane, Reports

Strong Mineralization in Drill Hole LE21-107

Saskatoon, SK, November 16, 2021 – IsoEnergy Ltd. (“IsoEnergy” or the “Company”) (TSXV: ISO; OTCQX: ISENF) is

pleased to announce the remaining scintillometer results from its successful summer drilling at the Hurricane zone.

Hurricane is a high -grade uranium project located on the Company’s 100% owned Larocque East property (the

“Property”) in the Eastern Athabasca Basin of Saskatc hewan. 2021 d rilling at Hurricane has now concluded and

planning is underway for the follow-up program early in 2022.

Highlights:

• Expansion of the mineralized footprint 31m to the south on Section 4485E and 17m to the south on Section

4460E

• Discovery of a new zone of strong mineralization south of the strongly mineralized zone defined in 2020

• Identification by drill hole LE21-101 of an area with potential for continued growth south and east of known

mineralization

Tim Gabruch, President and Chief Executive Officer commented: “We are pleased that our summer drilling program

at Larocque East has been safely and successfully completed. Drilling at Hurricane continue d to grow the zone of

uranium mineralization in line w ith our objectives and strategy. Given th ese scintillometer results, combined with

the program’s initial results released in September 2021, it has been a successful drilling campaign, and we look

forward to the winter program commencing in January 2022 to test further potential. Additionally, we have begun

to receive some assay results , which we expect to release shortly . It is anticipat ed that the balan ce of the assay

results will be received before the end of December.”

Andy Carmichael, Vice President of Exploration commented: “ The team has had continued success expanding the

western side of the Hurricane zone to the south. As well, the identification of an area in the immediate vicinity of

Hurricane (drill hole LE21 -101) with potential for continued growth is encouraging and we look forward to

commencing our next program.”

Note: Radioactivity is total gamma counts per second (CPS) fr om drill core measured with an RS -125 hand -held

spectrometer (RS-125).

Southerly Expansion

LE21-107 (Section 4485E)

LE21-107 targeted the centre of a 26m gap between previously reported drill holes LE20 -71 (2.4% U3O8 over 2.0m)

and LE21-82 (4.5m >500 CPS including 1.0m >5,000 CPS). LE21-107 intersected 6.5m of uranium mineralization (>500

CPS) from 325.5 to 332.0m, including 3.5m of strong mineralization (>30,000 CPS) from 327.5 to 331.0m. Figures 2

and 3 show the location of the drill hole in plan and section view, respectively.

LE21-103 (Section 4485E)

Drill hole LE21- 103 targeted the unconformity 31m south of previously reported drill hole LE21 -82. LE21- 103

intersected 4.0m of uranium mineralization (500 CPS) from 334.5m to 338.5m which includes 0.5m >5,000 CPS from

337.5 to 338.0m. The results of LE21-103 expand the Hurricane zone 31m to the south and the mineralized footprint

is now at least 125m wide on section 4485E. Figures 2 and 3 show the drill hole in plan and section view, respectively.

LE21-87A (Section 4460E)

Drill hole LE21- 87A was completed 17 m south of previously reported drill hole LE21 -78C1 (12.0m averaging >500

CPS including 2.0m >30,000 CPS). LE21-87A intersected 7.5m of uranium mineralization (>500 CPS) from 331.0m to

338.5m, including 2.0m of mineralization exceeding 20,000 CPS from 336.0m to 338.0m and including 1.0m

exceeding 20,000 CPS from 334.0 to 335.0m. The mineralization in LE21-87A has expanded the Hurricane zone 17m

to the south and the mineralized footprint is now at least 86m wide on section 4460E. Figures 2 and 4 show the

location of the drill hole in plan and section view, respectively.

2021 drill holes LE21-87A, LE21-107 and LE21-78C1 define a new zone of strong mineralization located immediately

south of the strongly mineralized zone discovered in 2020 (Figure 2).

LE21-91 (Section 4510E)

Drill hole LE21- 91 was completed to test for easterly extensions of mineralization intersected by earlier 2021 drill

holes, targeting the unconformity 28m northeast of LE21 -82 and 47m east of LE21 -78C1. LE21-91 intersected 5.0m

of uranium mineralization (>500 CPS) from 336.0m to 341.0m. Two 0.5m subintervals >5,000 CPS were intersected;

an upper zone from 337.5 to 338.0m, and a lower zone from 338.5 to 339.0m. Figures 2 and 5 show the drill hole

location in plan and section view, respectively.

LE21-105 (Section 4535E)

Drill hole LE21-105 was completed to test for easterly extensions of mineralization intersected by LE21-91. LE21-105

reached the unconformity 2 1m east of LE21-91 at a depth of 341.5m, intersecting 0.5m of uranium mineralization

(>500 CPS) from 339.5 to 340.0m. Figure 2 shows the drill hole in plan view.

Continued Growth Potential

LE21-101 (Section 4785E)

Drill hole LE21-101 tested the unconformity in an area where graphitic basement bounded by the J- and L-Faults has

seen limited drilling. LE21- 101 intersected 4.5m of uranium mineralization (>500 CPS) from 324.5 to 329.0m

including 0.5m >5,000 CPS from 327.5 to 328.0 m. These results are considered encouraging as the unconformity

along this prospective, graphitic structural corridor is untested to the east and the nearest drill hole along strike to

the west is 150m away. Figures 2 and 6 show the drill hole in plan and section view, respectively.

LE21-89 and LE21-95A (Section 4885E)

Drill holes LE21 -89 and LE21 -95A were completed on section 4885E in the cent re of a 200m along -strike gap in

drilling. LE21-89 targeted the I-fault at the unconformity and located the J- and K-faults at depth. LE21-95A targeted

the K -fault at the unconformity. Neither drill hole intersected uranium mineralization. Significantly, LE21 -95A is

interpreted to have undershot the K -fault by 25m indicating the mineralization intersected by LE21- 101 remains

open to the east. Figure 2 shows the locations of drill holes LE21- 89 and LE21-95A in plan view.

Defining the Zone

LE21-85 (Section 4460E)

Drill hole LE21- 85 was drilled to follow up mineralization intersected by previously reported drill holes LE20- 57

(11.7% U 3O8 over 10.0m) and LE20- 38 (2.0% U 3O8 over 7.5m). LE21 -85 intersected two zones of weak uranium

mineralization (>500 CPS) comprising a 1.0m long upper zone from 321.5 to 322.5m and a 0.5m long lower zone

from 327.0m to 327.5m. Figures 2 and 4 show the location of the drill hole in plan and section view, respectively.

LE21-100 (Section 4635E)

Drill hole LE21-100 was drilled to test for mineralization east of historical drill hole KER -11 (0.06% U3O8 over 0.5m).

No mineralization was intersected. Figure 2 shows the drill hole location in plan v iew.

LE21-93 (Section 4435E) and LE21-97A (Section 4410E)

LE21-93 and LE21-97A were drilled to expand mineralization to the north on sections 4410E and 4435E, respectively.

LE21-93 targeted the unconformity 29m north of previously reported drill hole LE20-42 (0.4% U3O8 over 3.0m) and

intersected 0.5m of uranium mineralization (>500 CPS) 13m above the unconformity. LE21 -97A targeted the

unconformity 29m north of previously reported drill hole LE2 1-84 ( 3.0m >500 CPS); no mineralization was

intersected by LE21-97A. Mineralization is interpreted to be closed off to the north on section 4435E and potential

for continued northerly expansion on section 4410E is considered to be low. Figure 2 shows the location of drill holes

LE21-93 and LE21-97A in plan view.

The Larocque East Property and the Hurricane Zone

The 100% owned Larocque East property consists of 33 mineral claims totaling 16,780ha. Two of the project’s claims

distal to the Hurricane zone are subject to a 2% Net Smelter Returns Royalty of which 1% may be bought back for $1

million at IsoEnergy’s discretion. Larocque East is immediately adjacent to the north end of IsoEnergy’s Geiger

property and is 35km northwest of Orano Canada’s McClean Lake uranium mine and mill.

Along with other target areas, the Larocque East Property covers a 15 -kilometre-long northeast extension of the

Larocque Lake conductor system; a trend of graphitic metasedimenta ry basement rocks that is associated with

significant uranium mineralization at the Hurricane zone, and in several occurrences on Cameco Corp. and Orano

Canada Inc.’s neighbouring property to the southwest of Larocque East. The Hurricane zone was discover ed in July

2018 and was followed up with 29 drill holes in 2019 and an additional 48 drill holes in 2020. Dimensions are

currently 375m along-strike, up to 125m wide, and up to 12m thick. The zone is open for expansion along -strike to

the east and to the north and south on some sections . Mineralization is polymetallic and commonly straddles the

sub-Athabasca unconformity 320 m below surface. The best intersection to date is 38.8% U 3O8 over 7.5m in drill

hole LE20-76. Drilling at Cameco Corp.’s Larocque Lake zone on the neighbouring property to the southwest has

returned historical intersections of up to 29.9% U 3O8 over 7.0m in drill hole Q22- 040. Like the nearby Geiger

property, Larocque East is located adjacent to the Wollaston-Mudjatik transition zone - a major crustal suture related

to most of the uranium deposits in the eastern Athabasca Basin. Importantly, t he sandstone cover on the Property

is thin, ranging between 140m and 450m in previous drilling.

Table 1 – Summer 2021 Drilling Program Results

Hole-ID From (m) To (m) Length (m) Radioactivity1,2 Chemical Assays Orientation Hole Length Location

(CPS) U3O8 (%) Ni (%) (Azm/Dip) (m)

LE21-783,4 Abandoned before target 128.0 Section 4460E

LE21-78C14 248.5 260.5 12.0 >500 Pending 000/-90 323.0 Section 4460E

incl. 253.0 254.0 1.0 >5,000 Pending

and incl. 254.5 255.0 0.5 >5,000 Pending

and incl. 257.5 259.5 2.0 >30,000 Pending

and incl. 260.0 260.5 0.5 >5,000 Pending

and 266.0 266.5 0.5 >5,000 Pending

and 269.0 269.5 0.5 >500 Pending

LE21-804 325.0 325.5 0.5 >500 Pending 000/-90 431.0 Section 4435E

and 326.0 329.5 3.5 >500 Pending

incl. 326.0 328.0 2.0 >5,000 Pending

incl. 326.5 327.0 0.5 >30,000 Pending

LE21-824 326.5 327.0 0.5 >500 Pending 000/-90 368.0 Section 4485E

and 328.5 333.0 4.5 >500 Pending

incl. 331.0 332.0 1.0 >5,000 Pending

LE21-844 326.5 329.5 3.0 >500 Pending 000/-90 380.0 Section 4435E

incl. 328.0 328.5 0.5 >5,000 Pending

LE21-85 321.5 322.5 1.0 >500 Pending 000/-90 335.0 Section 4460E

and 327.0 327.5 0.5 >500 Pending

LE21-87 Abandoned before target 180/-80 71.0 Section 4460E

LE21-87A 331.0 338.5 7.5 >500 Pending 180/-80 470.0 Section 4460E

incl. 331.5 332.0 0.5 >5,000 Pending

and incl. 333.5 338.0 4.5 >5,000 Pending

incl. 334.0 335.0 1.0 >20,000 Pending

and incl. 336.0 338.0 2.0 >20,000 Pending

LE21-89 No significant mineralization 180/-75 431.0 Section 4885E

LE21-91 336.0 341.0 5.0 >500 Pending 180/-80 425.0 Section 4510E

incl. 337.5 338.0 0.5 >5,000 Pending

and incl. 338.5 339.0 0.5 >5,000 Pending

LE21-93 316.0 316.5 0.5 >500 Pending 000/-90 362.0 Section 4410E

LE21-95 Abandoned before target 180/-75 56.0 Section 4885E

LE21-95A No significant mineralization 180/-75 449.0 Section 4885E

LE21-97 Abandoned before target 180/-80 55.6 Section 4435E

LE21-97A No significant mineralization 180/-80 350.0 Section 4435E

LE21-100 No significant mineralization 180/-80 371.0 Section 4635E

LE21-101 324.5 329.0 4.5 >500 Pending 180/-80 374.0 Section 4785E

incl. 327.5 328.0 0.5 >5,000 Pending

LE21-103 330.0 330.5 0.5 >500 Pending 180/-80 368.0 Section 4485E

and 331.0 331.5 0.5 >500 Pending

and 334.5 338.5 4.0 >500 Pending

incl. 337.5 338.0 0.5 >5,000 Pending

LE21-105 339.5 340.0 0.5 >500 Pending 180/-80 380.0 Section 4535E

LE21-107 325.5 332.0 6.5 >500 Pending 000/-90 344.0 Section 4485E

incl. 326.0 326.5 0.5 >10,000 Pending

and incl. 327.5 331.0 3.5 >30,000 Pending

Notes: 1. Radioactivity is total gamma from drill core measured with an RS-125 hand-held spectrometer.

2. Measurements of total gamma cps on drill core are an indication of uranium content, but may not correlate with uranium chemical assays.

3. LE21-78C1 is a wedged off-cut from LE21-78 at 70 metres

4. Radioactivity previously disclosed

Figure 1 – Larocque East Property Map

Figure 2 – Hurricane Zone Drill Hole Location Map

Figure 3 – Section 4485E

Figure 4 – Section 4460E

Figure 5 – Section 4510E