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IsoEnergy Commences Drilling to Expand Hurricane Zone and Explore Larocque East Project, Provides Geiger Drilling Update

Drill Results Exploration Programs

IsoEnergy Commences Drilling to Expand Hurricane Zone and Explore

Larocque East Project, Provides Geiger Drilling Update

Saskatoon, SK, September 3, 2021 – IsoEnergy Ltd. (“ IsoEnergy” or the “ Company”) (TSXV: ISO; OTCQX: ISENF) is

pleased to announce that following the completion of drilling at it s Geiger property, drilling has commenced at its

100% owned Larocque East project, home to the Hurricane zone high-grade uranium deposit.

Tim Gabruch, President and Chief Executive Officer commented: “IsoEnergy’s summer exploration program has been

progressing well. We recently completed our 12-hole drill program at Geiger and the team has moved over to our

Larocque East project where drilling has now begun. The work at Geiger was completed successfully, and safely,

and marks IsoEnergy’s first drill program outside of the Larocque East property since the Hurricane z one was

discovered during the summer program in 2018. Work now transitions back to our flagship Larocque East site, home

of the Hurricane zone. We are excited to get back on the ground there, having delayed our return because of COVID-

19.

Andy Carmichael, Vice President of Exploration commented : “Drilling in 2020 was the most successful to date at

Hurricane with intersections of strong mineralization over significant widths leading to the identification of a high-

grade domain. The team is excited to resume growing the Hurricane zone as well as drill testing high -priority

exploration targets, particularly along the fertile Larocque Lake conductive trend.”

As announced on July 26 th, 2021, d iamond d rilling at Larocque East will comprise 30 drill hole s totalling 12,000

metres and will have three objectives: Expansion; Infill; and Exploration. Twelve drill holes are planned to expand

the footprint of the Hurricane zone and will include drilling at both the western and the eastern side s of the zone .

Four infill drill holes are planned between existing drill fences to provide val uable information on the continuity of

the higher-grade portions of the zone . Figure 2 shows the Expansion and Infill target areas in plan view. Fourteen

exploration drill holes are planned in two target areas. The main target area is a three-kilometre-long section of the

Larocque Lake trend where DC-resistivity signatures similar to that of Hurricane are present and historical drilling

has intersected alteration, structures, graphitic basement, and anomalous geochemistry. The second target a rea

includes trends of decreased resistivity in the sandstone and basement and is located southeast of and subparallel

to the Hurricane zone stratigraphy. Figure 3 shows the exploration target areas in plan view.

Geiger Drilling Complete

Diamond drilling at Geiger concluded in August. Twelve diamond drill holes totalling 4, 428 metres were completed

to evaluate an area where historical drill holes intersected anomalous results. Geological interpretation is underway

and geochemical assay results are expected in a few weeks . While several drill holes intersected positive features ,

the most n oteworthy result is the discovery of a zone of significant sandstone alteration associated with the 3B

electromagnetic (EM) conductor. The 3B conductor was identified by IsoEnergy in July, during a reinterpretation of

historical airborne geophysical survey data (Figure 4).

The newly discovered alteration zone was first intersected by drill hole GG21- 21 while following- up anomalous

historical drill hole Q3- 006 by evaluating the 3A conductor (Figure 4) . GG21 -21 intersected wide intervals of

moderately to strongly b leached sandstone cored by a 50 -metre-long interval hosting structurally controlled clay

enrichment, desilicified zones, and l ocal hydrothermal hematite centred 100 metres south of the 3A conductor

(Figure 5). GG21-27 followed-up GG21 -21 by evaluat ing the sub-parallel 3B conductor and locat ing inferred

basement structure s controlling the alteration in the overlying sandstone . GG21-27 intersected moderately to

strongly bleached intervals in the sandstone as well as a zone of graphitic faulting in the basement 155 metres below

the unconformity which correlates to the centre of the 50-metre zone of increased alteration and structure in GG21-

21. Importantly, the 3B conductor associated with this sandstone alteration and graphitic basement has been tested

only indirectly by the two 2021 drill holes and is completely untested along its remaining 4.5 kilometres of strike

length (Figure 4).

The Larocque East Property and the Hurricane Zone

The 100% owned Larocque East property consists of 33 mineral claims totaling 16,780ha. Two of the project’s claims

distal to the Hurricane zone are subject to a 2% Net Smelter Returns Royalty of which 1% may be bought back for

$1Million at IsoEnergy’s discretion . Larocque East is immediately adjacent to th e north end of IsoEnergy’s Geiger

property and is 35km northwest of Orano Canada’s McClean Lake uranium mine and mill.

Along with other target areas, the Larocque East Property covers a 15 -kilometre-long northeast extension of the

Larocque Lake conductor s ystem; a trend of graphitic metasedimentary basement rocks that is associated with

significant uranium mineralization at the Hurricane zone, and in several occurrences on Cameco Corp. and Orano

Canada Inc.’s neighbouring property to the southwest of Larocque East. The Hurricane zone was discovered in July

2018 and was followed up with 29 drill holes in 2019 and an additional 48 drill holes in 2020. Dimensions are

currently 575m along-strike, up to 75m wide, and up to 11m thick. The zone is open for expansion along -strike to

the east and to the north and south on some sections. Mineralization is polymetallic and commonly straddles the

sub-Athabasca unconformity 320 m below surface. The best intersection to date is 38.8% U 3O8 over 7.5m in drill

hole LE20-76. Drilling at Cameco Corp.’s Larocque Lake zone on the neighbouring property to the southwest has

returned historical intersections of up to 29.9% U 3O8 over 7.0m in drill hole Q22- 040. Like the nearby Geiger

property, Larocque East is located adjacent to the Wollaston-Mudjatik transition zone - a major crustal suture related

to most of the uranium deposits in the eastern Athabasca Basin. Importantly, the sandstone cover on the Property

is thin, ranging between 140m and 450m in previous drilling.

Figure 1 – IsoEnergy Athabasca Basin Projects

Figure 2 – Larocque East Expansion and Infill Drilling Areas

Figure 3 – Larocque East Exploration Drilling Areas

Figure 4 – Geiger 2021 Drilling Plan View with Section Q3-3700E Location (UNDER CONSTRUCTION)

Figure 5 – Section Q3-3700E (Drill Holes GG21-21 and GG21-27) (UNDER CONSTRUCTION)

Qualified Person Statement

The scientific and technical information contained in this news release was prepared by Andy Carmichael, P.Geo.,

IsoEnergy’s Vice President, Exploration, who is a “Qualified Person” (as defined in NI 43-101 – Standards of Disclosure

for Mineral Projects). Mr. Carmichael has verified the data disclosed. As mineralized drill holes at the Hurricane zone

are oriented very steeply (-70 to -90 degrees) into a zone of mineralization that is interpreted to be horizontal, the

true thickness of the intersections is expected to be greater than or equal to 90% of the core lengths. This news

release refers to properties other tha n those in which the Company has an interest. Mineralization on those other

properties is not necessarily indicative of mineralization on the Company’s properties. For additional information

regarding the Company’s Larocque East Project, including its qual ity assurance and quality control procedures,

please see the Technical Report dated effective May 15, 2019, on the Company’s profile at www.sedar.com.

About IsoEnergy

IsoEnergy is a well-funded uranium exploration and development company with a portfolio of prospective projects

in the eastern Athabasca Basin in Saskatchewan, Canada. The Company recently discovered the high- grade

Hurricane Zone of uranium mineralization on its 100% owned Larocque East property in the Eastern Athabasca Basin.

IsoEnergy is led by a Board and Management team with a track record of success in uranium exploration,

development, and operations. The Company was founded and is supported by the tea m at its major shareholder,

NexGen Energy Ltd.

Tim Gabruch

President and Chief Executive Officer

IsoEnergy Ltd.

+1 306-261-6284

[email protected]

www.isoenergy.ca

Investor Relations

Kin Communications

+1 604 684 6730

[email protected]

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the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

This news release shall not constitute an offer to sell or a solicitation of any offer to buy any securities , nor shall

there be any sale of any securities in any jurisdiction in which such offer, solicitation or sale would be unlawful. The

securities referenced herein have not been, nor will they be, registered under the United States Securities Act of

1933, as amended (the “U.S. Securities Act”), and such securities may not be offered or sold within the United States

absent registration under the U.S. Securities Act or an applicable exemption from the registration requirements

thereunder.

Forward-Looking Information

The information contained herein contains “forward- looking statements” within the meaning of the United States

Private Securities Litigation Reform Act of 1995 and “forward-looking information” within the meaning of applicable

Canadian securities legislation. “Forward -looking inform ation” includes, but is not limited to, statements with

respect to the activities, events or developments that the Company expects or anticipates will or may occur in the

future, including, without limitation, planned exploration activities. Generally, but not always, forward -looking

information and statements can be identified by the use of words such as “plans”, “expects”, “is expected”,

“budget”, “scheduled”, “estimates”, “forecasts”, “intends”, “anticipates”, or “believes” or the negative connotation

thereof or variations of such words and phrases or state that certain actions, events or results “may”, “could”,

“would”, “might” or “will be taken”, “occur” or “be achieved” or the negative connotation thereof.

Such forward-looking information and statement s are based on numerous assumptions, including among others,

that the results of planned exploration activities are as anticipated, the price of uranium, the anticipated cost of

planned exploration activities, that general business and economic conditions will not change in a material adverse

manner, that financing will be available if and when needed and on reasonable terms, that third party contractors,

equipment and supplies and governmental and other approvals required to conduct the Company’s planned

exploration activities will be available on reasonable terms and in a timely manner. Although the assumptions made

by the Company in providing forward- looking information or making forward- looking statements are considered

reasonable by management at the time, there can be no assurance that such assumptions will prove to be accurate.

Forward-looking information and statements also involve known and unknown risks and uncertainties and other

factors, which may cause actual events or results in future periods to differ materially from any projections of future

events or results expressed or implied by such forward-looking information or statements, including, among others:

negative operating cash flow and dependence on third party financing, uncertainty of addit ional financing, no

known mineral reserves or resources, the limited operating history of the Company, the influence of a large

shareholder, alternative sources of energy and uranium prices, aboriginal title and consultation issues, reliance on

key manage ment and other personnel, actual results of exploration activities being different than anticipated,

changes in exploration programs based upon results, availability of third party contractors, availability of equipment

and supplies, failure of equipment t o operate as anticipated; accidents, effects of weather and other natural

phenomena and other risks associated with the mineral exploration industry, environmental risks, changes in laws

and regulations, community relations and delays in obtaining governmental or other approvals.

Although the Company has attempted to identify important factors that could cause actual results to differ

materially from those contained in the forward- looking information or implied by forward- looking information,

there may be o ther factors that cause results not to be as anticipated, estimated or intended. There can be no

assurance that forward-looking information and statements will prove to be accurate, as actual results and future

events could differ materially from those anticipated, estimated or intended. Accordingly, readers should not place

undue reliance on forward -looking statements or information. The Company undertakes no obligation to update

or reissue forward -looking information as a result of new information or events except as required by applicable

securities laws.