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IsoEnergy Appoints Graham du Preez as Chief Financial Officer

Management Changes

IsoEnergy Appoints Graham du Preez as Chief Financial Officer

Saskatoon, SK, March 3, 2022 – IsoEnergy Ltd. (“IsoEnergy”) (TSXV: ISO; OTCQX: ISENF) is pleased to announce the

appointment of Graham du Preez to the position of Chief Financial Officer. Mr. du Preez will be taking over the role

from Ms. Janine Richardson who has resigned from the position.

Tim Gabruch, Chief Executive Officer commented: “On behalf of the Board and everyone at IsoEnergy , I am very

happy to welcome Graham as Chief Financial Officer. Graham is a seasoned financial executive that brings extensive

experience from a variety of public mining companies , including within the uranium mining sector. We are excited

to hav e someone with Graham’s depth of experience join the organization as we work to continue growing and

developing IsoEnergy at an exciting time for the Company and the nuclear industry in general. We also look forward

to welcoming Graham and his family to Saskatoon as they relocate from Toronto. Additionally, I would like to thank

Janine for all of her efforts as CFO of IsoEnergy through a period of tremendous growth since its founding by NexGen

in 2016.”

Graham du Preez

Graham du Preez has more than a decade of experience as Chief Financial Officer with several public mining

companies in a variety of commodities and at various stages along the mining cycle. Most recently, Mr. du Preez

served as Chief Financial Officer at Harte Gold Corp. Prior to that, Mr. du Preez spent several years working in the

uranium industry, with Uranium One, Inc., including as Chief Financial Officer . Mr. du Preez has gained significant

experience contributing to a wide range of functional areas. This has included closing various financings, identifying

and participating in merger s and acquisition s, interacting with regulators, investors and analysts , undertaking

strategic planning, managing public filings , developing and managing operating budgets, and overseeing large

finance teams with broad responsibilities including accounting, payroll, tax, treasury, insurance and external

reporting.

In connection with the appointment of Mr. du Preez as the Company’s Chief Financial Officer, he has been granted

400,000 incentive stock options (the “Options”). The Options are exercisable at a price of $4.96, vest in three equal

annual instalments commencing on the grant date and have a term of five years. The Options were granted pursuant

to the Company’s incentive stock option plan and are subject to regulatory approval.

About IsoEnergy

IsoEnergy is a well-funded uranium exploration and development company with a portfolio of prospective projects

in the eastern Athabasca Basin in Saskatchewan, Canada. The Company recently discovered the high- grade

Hurricane Zone of uranium mineralization on its 100% owned Larocque East property in the Eastern Athabasca Basin.

IsoEnergy is led by a Board and Management team with a track record of success in uranium exploration,

development and operations. The Company was founded and is supported by the team at its major shareholder,

NexGen Energy Ltd.

Tim Gabruch

Chief Executive Officer

IsoEnergy Ltd.

+1 306 261-6284

[email protected]

www.isoenergy.ca

Investor Relations

Kin Communications

+1 604 684 6730

[email protected]

www.isoenergy.ca

Neither the TSX Venture Exchange nor its Regulations Services Provider (as that term is defined in the policies of

the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

This news release shall not constitute an offer to sell or a solicitation of any offer to buy any securities, nor shall

there be any sale of any securities in any jurisdiction in which such offer, solicitation or sale would be unlawful. The

securities referenced herein have not been, nor will they be, registered under the United States Securities Act of

1933, as amended (the “U.S. Securities Act”), and such securities may not be offered or sold within the United States

absent registration under the U.S. Securities Act or an applicable exemption from the registration requirements

thereunder.

Forward-Looking Information

The information contained herein contains “forward -looking statements” within the meaning of the United States

Private Securities Litigation Reform Act of 1995 and “forward-looking information” within the meaning of applicable

Canadian securities legislation. “Forward -looking information” includes , but is not limited to, statements with

respect to the activities, events or developments that the Company expects or anticipates will or may occur in the

future, including, without limitation, planned exploration activities. Generally, but not always, fo rward-looking

information and statements can be identified by the use of words such as “plans”, “expects”, “is expected”,

“budget”, “scheduled”, “estimates”, “forecasts”, “intends”, “anticipates”, or “believes” or the negative connotation

thereof or variat ions of such words and phrases or state that certain actions, events or results “may”, “could”,

“would”, “might” or “will be taken”, “occur” or “be achieved” or the negative connotation thereof.

Such forward-looking information and statements are based on numerous assumptions, including among others,

that the results of planned exploration activities are as anticipated, the price of uranium, the anticipated cost of

planned exploration activities, that general business and economic conditions will not change in a material adverse

manner, that financing will be available if and when needed and on reasonable terms, that third party contractors,

equipment and supplies and governmental and other approvals required to conduct the Company’s planned

exploration activities will be available on reasonable terms and in a timely manner. Although the assumptions made

by the Company in providing forward- looking information or making forward- looking statements are considered

reasonable by management at the time, there can be no assurance that such assumptions will prove to be accurate.

Forward-looking information and statements also involve known and unknown risks and uncertainties and other

factors, which may cause actual events or results in future periods to differ materially from any projections of future

events or results expressed or implied by such forward-looking information or statements, including, among others:

negative operating cash flow and dependence on third party financing, uncertainty of additional financing, no

known mineral reserves or resources, the limited operating history of the Company, the influence of a large

shareholder, alternative sources of energy and uranium prices, aboriginal title and consultation issues, reliance on

key management and other personnel, actual results of exploration activities being different than anticipated,

changes in exploration programs based upon results, availability of third party contractors, availability of equipment

and supplies, failure of equipment to operate as anticipated; accidents, effects of weather and other natural

phenomena and other risks associated with the mineral exploration industry, environmental risks, changes in laws

and regulations, community relations and delays in obtaining governmental or other approvals.

Although the Company has attempted to identify important factors that could cause actual results to differ

materially from those contained in the forward- looking information or implied by forward- looking information,

there may be other factors that cause results not to be as anticipated, estimated or intended. There can be no

assurance that forward-looking information and statements will prove to be accurate, as actual results and future

events could differ materially from those anticipated, estimated or intended. Accordingly, readers should not place

undue reliance on forward -looking statements or information. The Company undertakes no obligation to update

or reissue forward -looking information as a result of new information or events except as r equired by applicable

securities laws