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IsoEnergy Announces Winter 2023 Exploration Program

Exploration Programs

IsoEnergy Announces Winter 2023 Exploration Program

Saskatoon, SK, January 12, 2023 – IsoEnergy Ltd. (“IsoEnergy” or the “ Company”) (TSXV: ISO; OTCQX:

ISENF) is pleased to announce that exploration plans have been finalized for the winter 2023 season.

Highlights:

• Diamond drilling at Larocque East and Hawk totalling 6800m in 12 drill holes

• Ground geophysical surveys at Larocque East and Geiger

Tim Gabruch, President and Chief Executive Officer commented: “This winter, IsoEnergy will continue to

explore its diverse portfolio of prospective projects. The team is mobilizing now, and diamond drilling at

Larocque East will follow-up on the encouraging basement alteration zone intersected in the summer of

2022. IsoEnergy will also complete its first drill program at the Hawk Project, which covers 10 km of a

highly underexplored conductive trend in the infrastructure -rich eastern Athabasca Basin. Geophysical

programs at Larocque East and Geiger will generate and refine drill targets, ensuring a s teady stream of

exploration for several seasons to come . Having recently completed our $18.3 million financing in

December, IsoEnergy is well positioned to undertake this exciting exploration program and development

work at a time when the nuclear industry and the uranium sector in particular looks incredibly strong as

we move into 2023 and beyond.”

Larocque East Project

Six diamond drill holes totalling 2000 m are planned at Larocque East to follow up favourable results on

the eastern Kernaghan Trend. The 3.5 km of this conductive trend covered by the Larocque East project

has only been drilled on a single fence , where h istorical drilling intersected a nomalous uranium

geochemistry and chlorite in the lower sandstone and defined over 40 m of unconformity relief on section.

Following up the historical results, IsoEnergy’s summer 2022 drill hole LE22-144 intersected a broad zone

of illitic and hematitic alteration associated with a basement -hosted structure. The structure and

alteration are located in the 265 m gap between the historical drill holes. Winter 2023 drilling is planned

as a series of systematic step outs along strike of LE22-144 to evaluate the extent of the alteration zone

and test for the presence of mineralization. Figure 2 shows the planned drill hole locations.

Two lines of ground electromagnetic (EM) surveying are planned along the approximately 15 km long

interpreted western extension of the Kernaghan Trend. This work will generate drill targets for first-pass

evaluation of this undrilled portion of the Kernaghan Trend. Figure 2 shows the survey line locations.

Hawk Project Diamond Drilling

Six diamond drill holes, totalling 4800 m, are planned at IsoEnergy’s Hawk project during the winter 2023

season. Drilling will follow -up results from the 2022 EM survey which identified multiple moderate to

strong basement conductors in each of the three survey ed areas. Winter 2023 drilling will consist of

first-pass testing of each area to assess for the presence of significant alteration, structure, and

geochemistry. Figure 3 shows the planned drill hole locations.

Hawk is interpreted to cover at least 10 km of prospective conductive strike with depths to the

unconformity interpreted to be between 600 and 750 metres. The single historical drill hole completed

within the project, OR11 -06, failed to intersect conductive basement ; therefore, the prospective

stratigraphy is considered to remain un tested. Relogging of OR1 1-06 in 2022 by IsoEnergy identified

pervasively bleached and locally desilicified lower sandstones above pervasively sericitized basement,

which is suggestive of hydrothermal alteration in the vicinity.

Geiger Project Geophysics

A ground EM survey is planned at Geiger to follow-up a trend of anomalous drilling results and generate

additional drill targets along strike of weak historical mineralization. IsoEnergy’s s ummer 2022 drill hole

GG22-31 intersected a zone of pervasive argillic alte ration extending 55 metres into the basement

associated with graphitic gneisses. Located 1.7 km along strike to the north of GG22 -31, historical drill

hole Q23-003 intersected a zone of basement alteration similar to that in GG22-31. A further 2.8 km north,

Fission 3.0 Corp.’s drill hole ML22 -006 is reported to have intersected basement- hosted radioactivity

associated with graphitic fault structures. These anomalous results are interpreted to occur along a 4.5

km long trend of which 3.4 km lies within the Geiger project. Importantly, only GG22 -31 and ML22-006

are interpreted to have intersected the targeted conductors, leaving the remainder of this trend

inadequately tested.

A ground EM survey is also planned north of historical drill hole Q24 -001 which intersected 0.11% U3O8

over 0.3 m (259.6 – 259.9m) at the unconformity within an alteration zone spanning the unconformity.

Q24-001 was followed up on section and along strike to the south but remains open to the north.

Figure 4 shows the planned Geiger survey areas.

Figure 1 – Athabasca Property Map

Figure 2 – Larocque East Planned Drilling and Geophysics

Figure 3 – Hawk Project Planned Drilling Areas

Figure 4 – Geiger Project Ground Geophysical Survey Areas

Qualified Person Statement

David Thomas, P.Geo., IsoEnergy’s Technical Advisor, is the “Qualified Person” (as defined in NI 43 -101

– Standards of Disclosure for Mineral Projects ) for the Company and has validated and approved the

technical and scientific content of this news release. All 'GG' and 'LE' series drill holes were completed by

IsoEnergy, and geochemical analyses were completed for the Company by SRC Geoanalytical Laboratories

in Saskatoon, Saskatchewan. All other drill holes were completed by previous operators and geochemical

assay data has been compiled from historical assessment reports or provided by the previous operator(s).

For additional information regarding the Company’s Larocque East Project, including its quality assurance

and quality control procedures applied to the exploration work described in this news release, please see

the Technical Report titled “Technical Report on the Larocque East Project, Northern Saskatchewan,

Canada” dated August 4, 2022, on the Company’s profile at www.sedar.com .This news release refers to

properties other than those in which the Company has an interest. Mineralization on those other

properties is not necessarily indicative of mineralization on the Company’s properties.

About IsoEnergy

IsoEnergy is a well-funded uranium exploration and development company with a portfolio of prospective

projects in the infrastructure -rich eastern Athabasca Basin in Saskatchewan, Canada. In 2018, the

Company discovered the high-grade Hurricane Deposit on its 100% owned Larocque East property in the

Eastern Athabasca Basin. The Hurricane Deposit has Indicated Mineral Resources of 48.61 Million lb U3O8

based on 63,800 tonnes grading 34.5% U3O8 and Inferred Mineral Resources of 2.66 Million lb U3O8 based

on 54,300 tonnes grading 2.2% U 3O8 (July 8, 2022). The Hurricane Deposit is 100% owned by IsoEnergy

and is unencumbered from any royalties. IsoEnergy is led by a Board and Management team with a track

record of success in uranium exploration, development, and operations. The Company was founded and

is supported by the team at its major shareholder, NexGen Energy Ltd.

Tim Gabruch

President and Chief Executive Officer

IsoEnergy Ltd.

+1 306-261-6284

[email protected]

www.isoenergy.ca

Investor Relations

Kin Communications

+1 604 684 6730

[email protected]

Neither the TSX Venture Exchange nor its Regulations Services Provider (as that term is defined in the

policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

This news release shall not constitute an offer to sell or a solicitation of any offer to buy any securities, nor

shall there be any sale of any securities in any jurisdiction in which such offer, solicitation or sale would be

unlawful. The securities referenced herein have not been, nor will they be, registered under the United

States Securities Act of 1933, as amended (the “ U.S. Securities Act ”), and such securities may not be

offered or sold within the United States absent registration under the U.S. Securities Act or an applicable

exemption from the registration requirements thereunder.

Forward-Looking Information

The information contained herein contains “forward-looking statements” within the meaning of the United

States Private Securities Litigation Reform Act of 1995 and “forward- looking information” within the

meaning of applicable Canadian securities legislation. “Forward-looking information” includes, but is not

limited to, statements with respect to the activities, events or developments that the Company expects or

anticipates will or may occur in the future, including, without limitation, planned exploration activities.

Generally, but not always, forward- looking information and statements can be identified by the use of

words such as “plans”, “expects”, “is expected”, “budget”, “scheduled”, “estimates”, “forecasts”,

“intends”, “anticipates”, or “believes” or the negative connotation thereof or variations of such words and

phrases or state that certain actions, events or results “may”, “could”, “would”, “might” or “will be taken”,

“occur” or “be achieved” or the negative connotation thereof.

Such forward-looking information and statements are based on numerous assumptions, including among

others, that the results of planned exploration activities are as anticipated, the price of uranium, the

anticipated cost of planned exploration activities, that general business and economic conditions will not

change in a material adverse manner, that financing will be available if and when needed and on

reasonable terms, that third party contractors, equipment and supplies and governmental and other

approvals required to conduct the Company’s planned exploration activities will be available on reasonable

terms and in a timely manner. Although the assumptions made by the Company in providing forward-

looking information or making forward-looking statements are considered reasonable by management at

the time, there can be no assurance that such assumptions will prove to be accurate.

Forward-looking information and statements also involve known and unknown risks and uncertainties and

other factors, which may cause actual events or results in future periods to differ materially from any

projections of future events or results expressed or implied by such forward- looking information or

statements, including, among others: negative operating cash flow and dependence on third party

financing, uncertainty of additional financing, no known mineral reserves or resources, the limited

operating history of the Company, the influence of a large shareholder, alternative sources of energy and

uranium prices, aboriginal title and consultation issues, reliance on key management and other personnel,

actual results of exploration activities being different than anticipated, changes in exploration programs

based upon results, availability of third party contractors, availability of equipment and supplies, failure of

equipment to operate as anticipated; accidents, effects of weather and other natural phenomena and

other risks associated with the mineral exploration industry, environmental risks, changes in laws and

regulations, community relations and delays in obtaining governmental or other approvals.

Although the Company has attempted to identify important factors that could cause actual results to differ

materially from those contained in the forward- looking information or implied by forward- looking

information, there may be other factors that cause results not to be as anticipated, estimated or intended.

There can be no assurance that forward-looking information and statements will prove to be accurate, as

actual results and future events could diffe r materially from those anticipated, estimated or intended.

Accordingly, readers should not place undue reliance on forward-looking statements or information. The

Company undertakes no obligation to update or reissue forward- looking information as a resul t of new

information or events except as required by applicable securities laws.