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IsoEnergy Announces Initial Assay Results from Hurricane Expansion Drill Holes

Drill Results

IsoEnergy Announces Initial Assay Results from Hurricane Expansion

Drill Holes

Saskatoon, SK, December 1, 2021 – IsoEnergy Ltd. (“IsoEnergy” or the “Company”) (TSXV: ISO; OTCQX: ISENF) is

pleased to announce chemical assay results from the first four drill holes completed during the summer drilling

campaign at the Hurricane zone. These assays correspond to the scintillometer results reported in IsoEnergy’s

September 21, 2021, news release. With respect to further information related to the other drill holes recently

completed at Larocque East, remaining chemical assays are pending. Hurricane was discovered in July 2018 and is a

high-grade uranium project located on the Company’s 100% owned Larocque East property (the “Property”) in the

Eastern Athabasca Basin of Saskatchewan.

Table 1 – Summer 2021 Drilling Program Results

Hole From To Length Radioactivity 1,2

ID (m) (m) (m) (CPS) U 3O8 (%) Ni (%)

LE21-784 Abandoned before target Section 4460E

LE21-78C13,4 248.5 260.5 12.0 >500 5.2 1.1 Section 4460E

incl. 253.0 254.0 1.0 >5,000 1.5 2.3

and incl. 254.5 255.0 0.5 >5,000 1.7 0.3

and incl. 257.5 259.5 2.0 >30,000 27.6 3.6

and incl. 260.0 260.5 0.5 >5,000 1.9 0.1

and 266.0 266.5 0.5 >5,000 1.9 0.7

LE21-804 325.0 325.5 0.5 >500 0.1 0.0 Section 4435E

and 326.0 329.5 3.5 >500 2.3 0.1

incl. 326.0 328.0 2.0 >5,000 4.0 0.2

incl. 326.5 327.0 0.5 >30,000 9.0 0.4

LE21-824 326.5 327.0 0.5 >500 0.2 0.1 Section 4485E

and 328.5 333.0 4.5 >500 0.9 7.2

incl. 331.0 332.0 1.0 >5,000 1.4 16.2

LE21-844 326.5 329.5 3.0 >500 0.5 0.6 Section 4435E

incl. 328.0 328.5 0.5 >5,000 1.9 0.2

LE21-854 321.5 322.5 1.0 >500 Pending Section 4460E

and 327.0 327.5 0.5 >500 Pending

LE21-874 Abandoned before target Section 4460E

LE21-87A4 331.0 338.5 7.5 >500 Pending Section 4460E

incl. 331.5 332.0 0.5 >5,000 Pending

and incl. 333.5 338.0 4.5 >5,000 Pending

incl. 334.0 335.0 1.0 >20,000 Pending

and incl. 336.0 338.0 2.0 >20,000 Pending

LE21-894 No significant mineralization Section 4885E

LE21-914 336.0 341.0 5.0 >500 Pending Section 4510E

incl. 337.5 338.0 0.5 >5,000 Pending

and incl. 338.5 339.0 0.5 >5,000 Pending

Chemical Assays Location

Notes:

1. Radioactivity is total gamma from drill core measured with an RS-125 hand-held spectrometer.

2. Measurements of total gamma cps on drill core are an indication of uranium content but may not correlate with uranium chemical

assays.

3. LE21-78C1 is a wedged off-cut LE21-78 at 70m

4. Radioactivity previously disclosed

Andy Carmichael, Vice President of Exploration commented: “The grade and thickness of mineralization in LE21-

78C1 coupled with the radioactivity intersected by LE21-87A and LE21-107 is evidence that further potential remains

at the J-L fault corridor. We look forward to exploring this prospective corridor in 2022, particularly along strike of

LE21-101 as this area is untested for 150m to the west and open to the east.”

Tim Gabruch, President and Chief Executive Officer commented: “The summer drill program was successful in

continuing to enhance our understanding of the Hurricane zone. These initial assay results continue to demonstrate

the potential of the zone and we are looking forward to returning to Hurricane this winter to follow up on these

excellent results.”

LE21-78C1 (Section 4460E)

LE21-78C1 was drilled on Section 4460E to expand mineralization to the south of drill hole LE20-77 (8.0m averaging

2.6% U 3O8). The drill hole intersected 12.0m of uranium mineralization from 248.5 to 260.5m that averages 5.2%

U3O8, including 2.0m of strong mineralization from 257.5m to 259.5m that averages 27.6% U 3O8. Mineralization is

located at the sub-Athabasca unconformity. Figures 2 and 3 show the location of the drill hole in plan and section

view, respectively.

LE21-80 (Section 4435E)

Drill hole LE21-80 was completed to test for a north-easterly extension of very strong mineralization intersected by

previously reported drill hole LE20-34 (33.9% U 3O8 over 8.5m). The drill hole reached the unconformity 19m east-

northeast of LE20-34 and intersected 3.5m of uranium mineralization from 326.0m to 329.5m that averages 2.3%

U3O8, including 2.0m averaging 4.0% U 3O8 from 326.0 to 328.0m. Figures 2 and 4 show the drill hole in plan and

section view, respectively.

LE21-934 316.0 316.5 0.5 >500 Pending Section 4410E

LE21-954 Abandoned before target Section 4885E

LE21-95A4 No significant mineralization Section 4885E

LE21-974 Abandoned before target Section 4435E

LE21-97A4 No significant mineralization Section 4435E

LE21-1004 No significant mineralization Section 4635E

LE21-1014 324.5 329.0 4.5 >500 Pending Section 4785E

incl. 327.5 328.0 0.5 >5,000 Pending

LE21-1034 330.0 330.5 0.5 >500 Pending Section 4485E

and 331.0 331.5 0.5 >500 Pending

and 334.5 338.5 4.0 >500 Pending

incl. 337.5 338.0 0.5 >5,000 Pending

LE21-1054 339.5 340.0 0.5 >500 Pending Section 4535E

LE21-1074 325.5 332.0 6.5 >500 Pending Section 4485E

incl. 326.0 326.5 0.5 >10,000 Pending

and incl. 327.5 331.0 3.5 >30,000 Pending

LE21-82 (Section 4485E)

Drill hole LE21-82 was completed to expand mineralization to the south on Section 4485E. LE21-82 intersected 4.5m

of uranium mineralization from 328.5 to 333.0m that averages 0.9% U3O8, including 1.0m from 331.0 to 332.0m that

averages 1.4% U 3O8. The results this drill hole expanded the Hurricane zone 26m to the south on section 4485;

subsequently, LE21-103 (4.0m >500 CPS including 0.5m >5,000 CPS) expanded Hurricane a further 31m to the south

of LE21-82. Assays are pending for LE21-103. Figures 2 and 5 show the LE21-82 in plan and section view, respectively.

LE21-84 (Section 4435E)

Drill hole LE21-84 was completed on section with and 28m north of previously reported drill hole LE20-67 (0.2% U3O8

over 2.0m). The drill hole intersected 3.0m of uranium mineralization from 326.5m to 329.5m that averages 0.5%

U3O8, including 0.5m 1.4% U3O8 from 328.0 to 328.5m. This mineralization expanded the Hurricane zone 28m to the

north; mineralization was later closed off to the north on Section 4435E by drill hole LE21-97A. Figures 2 and 4 show

the drill hole in plan and section view, respectively.

The Larocque East Property and the Hurricane Zone

The 100% owned Larocque East property consists of 33 mineral claims totaling 16,780ha. Two of the project’s claims

distal to the Hurricane zone are subject to a 2% Net Smelter Returns Royalty of which 1% may be bought back for

$1Million at IsoEnergy’s discretion. Larocque East is immediately adjacent to the north end of IsoEnergy’s Geiger

property and is 35km northwest of Orano Canada’s McClean Lake uranium mine and mill.

Along with other target areas, the Larocque East Property covers a 15-kilometre-long northeast extension of the

Larocque Lake conductor system; a trend of graphitic metasedimentary basement rocks that is associated with

significant uranium mineralization at the Hurricane zone, and in several occurrences on Cameco Corp. and Orano

Canada Inc.’s neighbouring property to the southwest of Larocque East. The Hurricane zone was discovered in July

2018 and was followed up with 29 drill holes in 2019 and an additional 48 drill holes in 2020. Dimensions are currently

375m along-strike, up to 125m wide, and up to 12m thick. Mineralization is polymetallic and commonly straddles

the sub-Athabasca unconformity 320 m below surface. The best intersection to date is 38.8% U3O8 over 7.5m in drill

hole LE20-76. Drilling at Cameco Corp.’s Larocque Lake zone on the neighbouring property to the southwest has

returned historical intersections of up to 29.9% U 3O8 over 7.0m in drill hole Q22-040. Like the nearby Geiger

property, Larocque East is located adjacent to the Wollaston-Mudjatik transition zone - a major crustal suture related

to most of the uranium deposits in the eastern Athabasca Basin. Importantly, the sandstone cover on the Property

is thin, ranging between 140m and 450m in previous drilling.

Figure 1 – Larocque East Property Map

Figure 2 – Western Hurricane Zone Drill Hole Location Map

Figure 3 – Section 4460E

Figure 4 – Section 4435E

Figure 5 – Section 4485E

Qualified Person Statement

The scientific and technical information contained in this news release was prepared by Andy Carmichael, P.Geo.,

IsoEnergy’s Vice President, Exploration, who is a “Qualified Person” (as defined in NI 43-101 – Standards of Disclosure

for Mineral Projects). Mr. Carmichael has verified the data disclosed. All radioactivity measurements reported herein

are total gamma from an RS-125 hand-held spectrometer. As mineralized drill holes at the Hurricane zone are

oriented very steeply (-70 to -90 degrees) into a zone of mineralization that is interpreted to be horizontal, the true

thickness of the intersections is expected to be greater than or equal to 90% of the core lengths. This news release

refers to properties other than those in which the Company has an interest. Mineralization on those other properties

is not necessarily indicative of mineralization on the Company’s properties. All chemical analyses are completed for

the Company by SRC Geoanalytical Laboratories in Saskatoon, SK. For additional information regarding the

Company’s Larocque East Project, including its quality assurance and quality control procedures, please see the

Technical Report dated effective May 15, 2019, on the Company’s profile at www.sedar.com.

About IsoEnergy

IsoEnergy is a well-funded uranium exploration and development company with a portfolio of prospective projects

in the eastern Athabasca Basin in Saskatchewan, Canada. The Company recently discovered the high-grade

Hurricane Zone of uranium mineralization on its 100% owned Larocque East property in the Eastern Athabasca Basin.

IsoEnergy is led by a Board and Management team with a track record of success in uranium exploration,

development, and operations. The Company was founded and is supported by the team at its major shareholder,

NexGen Energy Ltd.

Tim Gabruch

President and Chief Executive Officer

IsoEnergy Ltd.

+1 306-261-6284

[email protected]

www.isoenergy.ca

Investor Relations

Kin Communications

+1 604 684 6730

[email protected]

Neither the TSX Venture Exchange nor its Regulations Services Provider (as that term is defined in the policies of

the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

This news release shall not constitute an offer to sell or a solicitation of any offer to buy any securities, nor shall

there be any sale of any securities in any jurisdiction in which such offer, solicitation or sale would be unlawful. The

securities referenced herein have not been, nor will they be, registered under the United States Securities Act of

1933, as amended (the “U.S. Securities Act”), and such securities may not be offered or sold within the United States

absent registration under the U.S. Securities Act or an applicable exemption from the registration requirements

thereunder.

Forward-Looking Information

The information contained herein contains “forward-looking statements” within the meaning of the United States

Private Securities Litigation Reform Act of 1995 and “forward-looking information” within the meaning of applicable

Canadian securities legislation. “Forward-looking information” includes, but is not limited to, statements with

respect to the activities, events or developments that the Company expects or anticipates will or may occur in the

future, including, without limitation, planned exploration activities. Generally, but not always, forward-looking

information and statements can be identified by the use of words such as “plans”, “expects”, “is expected”,

“budget”, “scheduled”, “estimates”, “forecasts”, “intends”, “anticipates”, or “believes” or the negative connotation

thereof or variations of such words and phrases or state that certain actions, events or results “may”, “could”,

“would”, “might” or “will be taken”, “occur” or “be achieved” or the negative connotation thereof.