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Exploration Programs

NETRAMARK,

THE

FIRST

PUBLIC

AI

COMPANY

TO

LAUNCH

CLINICAL

TRIAL

DE-RISKING

TECHNOLOGY

THAT

INTEGRATES

CHATGPT

TORONTO,

ON,

May

16,

2023

NetraMark

Holdings

Inc

.

(the

“Company”

or

“NetraMark”)

(CSE:

AIAI)

(Frankfurt:

8TV)

(OTC:

AINMF)

announces

the

release

of

NetraGPT.

Through

newly

developed

algorithms,

NetraGPT

builds

upon

the

powerful

hypotheses

generated

from

the

Company’s

proprietary

Good

Clinical

Practice

(GCP)

validated

AI/

ML

system,

NetraAI.

The

power

of

the

NetraAI

system

lies

in

its

ability

to

learn

about

special

combinations

of

variables

that

define

patient

subpopulations

in

relation

to

drug

or

placebo

response

and

adverse

effects,

all

of

which

are

important

considerations

for

clinical

trials.

NetraGPT

now

revolutionizes

the

power

of

NetraAI

whereby

the

NetraAI

output

is

fed

into

generative

pre-trained

(GPT)

models

utilizing

Large

Language

Model

(LLM)

APIs.

Currently,

LLMs

are

being

trained

with

a

massive

volume

of

data,

with

ChatGPT4

being

trained

on

approximately

300

billion

words

of

data,

including

medical

literature.

This

innovation

places

NetraMark

in

a

unique

position

to

not

only

build

upon

the

hypothesis

and

subpopulation

definitions

derived

from

NetraAI

but

to

now

also

potentially

discover

further

insights

that

leverage

the

power

of

LLMs

and

deliver

the

output

reports

in

minutes

vs.

weeks.

This

creates

an

unprecedented

opportunity

for

NetraMark

to

seamlessly

integrate

output

from

NetraAI

and

quickly

convey

potent

insights

about

patient

populations

to

our

clientele

with

heightened

efficiency

and

explainability.

NetraGPT

NetraGPT

ingests

information

about

specific

clinical

trial

patient

subpopulations

discovered

by

NetraAI.

More

specifically,

this

involves

feeding

the

collection

of

variables,

biological

or

otherwise,

that

are

statistically

significant

for

the

discovered

subpopulations

of

interest,

based

on

the

dependent

variable,

e.g.,

drug

response,

placebo

response,

placebo

non-response,

adverse

event,

etc.

The

resulting

output

of

the

NetraGPT

module

is

a

detailed

human-readable

report

that

leverages

the

power

of

LLMs

and

the

massive

corpus

of

medical

literature

to

provide:

Output

reports

that

begin

to

assemble

in

seconds

and

conclude

within

minutes

Improved

explainability

of

the

influential

variables

underlying

discovered

subpopulations

Additional

insights

delineating

interconnections

among

variables,

the

response,

and

the

disease

state

References

sourced

from

relevant

and

contemporary

literature

Importantly,

the

process

is

transparent

about

the

variables

driving

the

specific

patient

subpopulations

that

can

be

clearly

identified

and

validated

through

statistical

inspection.

This

level

of

transparency

is

critical

for

sponsors,

particularly

when

working

with

LLMs,

as

it

allows

human

experts

and

trialists

to

audit

parts

of

the

hypothesis-generation

artificial

intelligence

(AI)

process

and

the

LLM-generated

report,

to

ensure

the

veracity

of

the

generated

insights

and

recommendations.

“NetraGPT

is

a

critical

and

differentiated

offering

that

places

NetraMark

at

the

forefront

of

AI

innovation

for

clinical

trial

de-risking

in

the

Pharmaceutical

Industry.

This

will

allow

us

to

deliver

critical

insights

to

our

clients

very

quickly

and

allow

them

to

proceed

with

critical

trial

enrichment

decisions

faster

and

with

more

clarity.

This

is

an

exciting

time

for

the

Company,

as

we

share

NetraGPT

with

key

decision

makers

in

the

industry,”

said

Josh

Spiegel,

President

NetraMark.

“LLMs,

like

ChatGPT,

have

recently

achieved

a

level

of

sophistication

that

is

enabling

practical

innovation

for

a

variety

of

use

cases.

NetraAI

is

built

to

explain

what

it

finds

and

this

property

makes

our

technology

an

optimal

partner

for

ChatGPT.

Through

new

algorithm

development

at

NetraMark,

this

fusion

between

NetraAI

and

ChatGPT

provides

a

cutting

edge

insight

engine

for

clinical

trial

patient

populations

that

can

be

delivered

quickly

and

with

clarity,”

said

Dr.

Joseph

Geraci,

CTO

/

CSO

NetraMark.

Additional

information,

including

sample

outputs

from

NetraGPT,

can

be

found

here:

NetraGPT

White

Paper

About

NetraMark

NetraMark

is

a

company

focused

on

being

a

leader

in

the

development

of

Artificial

Intelligence

(AI)

/

Machine

Learning

(ML)

solutions

targeted

at

the

Pharmaceutical

industry.

Its

product

offering

uses

a

novel

topology-based

algorithm

that

has

the

ability

to

parse

patient

data

sets

into

subsets

of

people

that

are

strongly

related

according

to

several

variables

simultaneously.

This

allows

NetraMark

to

use

a

variety

of

ML

methods,

depending

on

the

character

and

size

of

the

data,

to

transform

the

data

into

powerfully

intelligent

data

that

activates

traditional

AI

/

ML

methods.

The

result

is

that

NetraMark

can

work

with

much

smaller

datasets

and

accurately

segment

diseases

into

different

types,

as

well

as

accurately

classify

patients

for

sensitivity

to

drugs

and

/

or

efficacy

of

treatment.

For

further

details

on

the

Company

please

see

the

Company’s

publicly

available

documents

filed

on

the

System

for

Electronic

Document

Analysis

and

Retrieval

(SEDAR).

Company

contact

information:

Swapan

Kakumanu

-

CFO

|

[email protected]

|

403-681-2549

Forward-Looking

Statements

This

press

release

contains

"forward-looking

information"

within

the

meaning

of

applicable

Canadian

securities

legislation

including

statements

regarding

the

power

of

NetraGPT

to

generate

hypothesis

and

reports

more

efficiently

with

improved

explainability

of

the

influential

variables

underlying

discovered

subpopulations,

additional

insights

into

interconnections

among

variables

and

the

response

and

the

disease

state

and

scientific

or

medical

references,

the

uniqueness

of

NetraMark’s

position

to

integrate

and

use

this

technology

and

the

ability

to

deliver

critical

insights

to

our

clients

quickly

and

allow

them

to

proceed

with

critical

trial

enrichment

decisions

faster

and

with

more

clarity

which

are

based

upon

NetraMark’s

current

internal

expectations,

estimates,

projections,

assumptions

and

beliefs,

and

views

of

future

events.

Forward-looking

information

can

be

identified

by

the

use

of

forward-looking

terminology

such

as

"expect",

"likely",

"may",

"will",

"should",

"intend",

"anticipate",

"potential",

"proposed",

"estimate"

and

other

similar

words,

including

negative

and

grammatical

variations

thereof,

or

statements

that

certain

events

or

conditions

"may",

"would"

or

"will"

happen,

or

by

discussions

of

strategy.

Forward-looking

information

includes

estimates,

plans,

expectations,

opinions,

forecasts,

projections,

targets,

guidance,

or

other

statements

that

are

not

statements

of

fact.

The

forward-looking

statements

are

expectations

only

and

are

subject

to

known

and

unknown,

risks,

uncertainties

and

other

important

factors

that

could

cause

actual

results

of

the

Company

or

industry

results

to

differ

materially

from

future

results,

performance

or

achievements.

Any

forward-looking

information

speaks

only

as

of

the

date

on

which

it

is

made,

and,

except

as

required

by

law,

NetraMark

does

not

undertake

any

obligation

to

update

or

revise

any

forward-looking

information,

whether

as

a

result

of

new

information,

future

events,

or

otherwise.

New

factors

emerge

from

time

to

time,

and

it

is

not

possible

for

NetraMark

to

predict

all

such

factors.

When

considering

these

forward-looking

statements,

readers

should

keep

in

mind

the

risk

factors

and

other

cautionary

statements

as

set

out

in

the

materials

we

file

with

applicable

Canadian

securities

regulatory

authorities

on

SEDAR

at

www.sedar.com

including

our

Management’s

Discussion

and

Analysis

for

the

year

ended

September

30,

2022.

These

risk

factors

and

other

factors

could

cause

actual

events

or

results

to

differ

materially

from

those

described

in

any

forward-looking

information.

The

CSE

does

not

accept

responsibility

for

the

adequacy

or

accuracy

of

this

release.